Select Publications

    Ahmed AU, Thaci B, Tobias AL, Auffinger B, Zhang L, Cheng Y, Kim CK, Yunis C, Han Y, Alexiades NG, Fan X, Aboody KS, Lesniak MS. A preclinical evaluation of neural stem cell-based cell carrier for targeted antiglioma oncolytic virotherapy. J Natl Cancer Inst. 2013;105(13):968-77. doi: 10.1093/jnci/djt141. PubMed PMID: 23821758; PMCID: PMC3699440.

    Appelbe OK, Zhang Q, Pelizzari CA, Weichselbaum RR, Kron SJ. Image-Guided Radiotherapy Targets Macromolecules through Altering the Tumor Microenvironment. Mol Pharm. 2016;13(10):3457-67. doi: 10.1021/acs.molpharmaceut.6b00465. PubMed PMID: 27560921; PMCID: PMC5103304.

    Barrero JJ, Papanikou E, Casler JC, Day KJ, Glick BS. An improved reversibly dimerizing mutant of the FK506-binding protein FKBP. Cell Logist 6:e1204848, 2016. PMC5058350

    Bockhorn J, Dalton R, Nwachukwu C, Huang S, Prat A, Yee K, Chang YF, Huo D, Wen Y, Swanson KE, Qiu T, Lu J, Park SY, Dolan ME, Perou CM, Olopade OI, Clarke MF, Greene GL, Liu H. MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun. 2013;4:1393. doi: 10.1038/ncomms2393. PubMed PMID: 23340433; PMCID: PMC3723106.

    Bockhorn J, Yee K, Chang YF, Prat A, Huo D, Nwachukwu C, Dalton R, Huang S, Swanson KE, Perou CM, Olopade OI, Clarke MF, Greene GL, Liu H. MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat. 2013;137(2):373-82. doi: 10.1007/s10549-012-2346-4. PubMed PMID: 23224145; PMCID: PMC3583223.

    Brechka H, McAuley EM, Lamperis SM, Paner GP, Vander Griend DJ. Contribution of Caudal Mullerian Duct Mesenchyme to Prostate Development. Stem Cells Dev 25:1733-1741, 2016. PMC5105354

    Cheng SH, Yu D, Tsai HM, Morshed RA, Kanojia D, Lo LW, Leoni L, Govind Y, Zhang L, Aboody KS, Lesniak MS, Chen CT, Balyasnikova IV. Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma. J Nucl Med. 2016;57(2):279-84. doi: 10.2967/jnumed.115.163006. PubMed PMID: 26564318.

    Cheng Y, Dai Q, Morshed RA, Fan X, Wegscheid ML, Wainwright DA, Han Y, Zhang L, Auffinger B, Tobias AL, Rincón E, Thaci B, Ahmed AU, Warnke PC, He C, Lesniak MS. Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging. Small. 2014;10(24):5137-50. doi: 10.1002/smll.201400654. PubMed PMID: 25104165; PMCID: PMC4268041.

    Cheng Y, Morshed R, Cheng SH, Tobias A, Auffinger B, Wainwright DA, Zhang L, Yunis C, Han Y, Chen CT, Lo LW, Aboody KS, Ahmed AU, Lesniak MS. Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. Small. 2013;9(24):4123-9. doi: 10.1002/smll.201301111. PubMed PMID: 23873826; PMCID: PMC3879136.

    Christodoulou, A. G., G. Redler, B. Clifford, Z. P. Liang, H. J. Halpern, and B. Epel. "Fast Dynamic Electron Paramagnetic Resonance (Epr) Oxygen Imaging Using Low-Rank Tensors." J Magn Reson 270 (Sep 2016): 176-82.

    Chung EJ, Cheng Y, Morshed R, Nord K, Han Y, Wegscheid ML, Auffinger B, Wainwright DA, Lesniak MS, Tirrell MV. Fibrin-binding, peptide amphiphile micelles for targeting glioblastoma. Biomaterials. 2014;35(4):1249-56. doi: 10.1016/j.biomaterials.2013.10.064. PubMed PMID: 24211079; PMCID: PMC3880134.

    Efimova EV, Takahashi S, Shamsi NA, Wu D, Labay E, Ulanovskaya OA, Weichselbaum RR, Kozmin SA, Kron SJ. Linking Cancer Metabolism to DNA Repair and Accelerated Senescence. Mol Cancer Res 14:173-84, 2016. PMC4755886

    Elas M, Magwood JM, Butler B, Li C, Wardak R, DeVries R, Barth ED, Epel B, Rubinstein S, Pelizzari CA, Weichselbaum RR, Halpern HJ. EPR oxygen images predict tumor control by a 50% tumor control radiation dose. Cancer Res. 2013;73(17):5328-35. doi: 10.1158/0008-5472.CAN-13-0069. PubMed PMID: 23861469; PMCID: PMC3913470.

    Epel B, Bowman MK, Mailer C, Halpern HJ. Absolute oxygen R1e imaging in vivo with pulse electron paramagnetic resonance. Magn Reson Med. 2014;72(2):362-8. doi: 10.1002/mrm.24926. PubMed PMID: 24006331; PMCID: PMC4318240.

    Epel B, Halpern HJ. In Vivo pO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance. Methods Enzymol. 2015;564:501-27. doi: 10.1016/bs.mie.2015.08.017. PubMed PMID: 26477263; PMCID: PMC4749023.

    Epel B, Redler G, Halpern HJ. How in vivo EPR measures and images oxygen. Adv Exp Med Biol. 2014;812:113-9. doi: 10.1007/978-1-4939-0620-8_15. PubMed PMID: 24729222; PMCID: PMC4319367.

    Epel B, Redler G, Pelizzari C, Tormyshev VM, Halpern HJ. Approaching Oxygen-Guided Intensity-Modulated Radiation Therapy. Adv Exp Med Biol. 2016;876:185-93. doi: 10.1007/978-1-4939-3023-4_23. PubMed PMID: 26782211; PMCID: PMC4747097.

    Fan X, Mustafi D, Markiewicz E, Zamora M, Vosicky J, Leinroth A, Mueller J, Macleod K, Conzen SD, Karczmar GS. Mammary cancer initiation and progression studied with magnetic resonance imaging. Breast Cancer Res. 2014;16(6):495. doi: 10.1186/s13058-014-0495-6. PubMed PMID: 25510596; PMCID: PMC4303211.

    Flor AC, Doshi AP, Kron SJ. Modulation of therapy-induced senescence by reactive lipid aldehydes. Cell Death Discov 2, 2016. PMC4957821

    Flor AC, Kron SJ. Lipid-derived reactive aldehydes link oxidative stress to cell senescence. Cell Death Dis 7:e2366, 2016. PMC5059874

    Foxley, S., M. Domowicz, G. S. Karczmar, and N. Schwartz. "3d High Spectral and Spatial Resolution Imaging of Ex Vivo Mouse Brain." Med Phys 42, no. 3 (Mar 2015): 1463-72.

    Gao Y, Huang E, Zhang H, Wang J, Wu N, Chen X, Wang N, Wen S, Nan G, Deng F, Liao Z, Wu D, Zhang B, Zhang J, Haydon RC, Luu HH, Shi LL, He TC. Crosstalk between Wnt/β-catenin and estrogen receptor signaling synergistically promotes osteogenic differentiation of mesenchymal progenitor cells. PLoS One. 2013;8(12):e82436. doi: 10.1371/journal.pone.0082436. PubMed PMID: 24340027; PMCID: PMC3855436.

    Hakim F, Wang Y, Zhang SX, Zheng J, Yolcu ES, Carreras A, Khalyfa A, Shirwan H, Almendros I, Gozal D. Fragmented sleep accelerates tumor growth and progression through recruitment of tumor-associated macrophages and TLR4 signaling. Cancer Res. 2014;74(5):1329-37. doi: 10.1158/0008-5472.CAN-13-3014. PubMed PMID: 24448240; PMCID: PMC4247537.

    Haney CR, Fan X, Markiewicz E, Mustafi D, Karczmar GS, Stadler WM. Monitoring anti-angiogenic therapy in colorectal cancer murine model using dynamic contrast-enhanced MRI: comparing pixel-by-pixel with region of interest analysis. Technol Cancer Res Treat. 2013;12(1):71-8. doi: 10.7785/tcrt.2012.500255. PubMed PMID: 22905809.

    Ikeda Y, Park JH, Miyamoto T, Takamatsu N, Kato T, Iwasa A, Okabe S, Imai Y, Fujiwara K, Nakamura Y, Hasegawa K. T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer. Clin Cancer Res 22:6110-6117, 2016.

    Labay E, Mauceri HJ, Efimova EV, Flor AC, Sutton HG, Kron SJ, Weichselbaum RR. Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers. Oncotarget 7:33919-33, 2016. PMC5085128

    Leventhal DS, Gilmore DC, Berger JM, Nishi S, Lee V, Malchow S, Kline DE, Kline J, Vander Griend DJ, Huang H, Socci ND, Savage PA. Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells. Immunity 44:847-59, 2016. PMC4842258

    Lu K, He C, Guo N, Chan C, Ni K, Weichselbaum RR, Lin W. Chlorin-Based Nanoscale Metal-Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy. J Am Chem Soc 138:12502-10, 2016.

    Lu R, Wu S, Zhang YG, Xia Y, Zhou Z, Kato I, Dong H, Bissonnette M, Sun J. Salmonella Protein AvrA Activates the STAT3 Signaling Pathway in Colon Cancer. Neoplasia 18:307-16, 2016. PMC4887618

    Luther GA, Lamplot J, Chen X, Rames R, Wagner ER, Liu X, Parekh A, Huang E, Kim SH, Shen J, Haydon RC, He TC, Luu HH. IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma. Cancer Lett. 2013;336(1):222-30. doi: 10.1016/j.canlet.2013.05.002. PubMed PMID: 23665505; PMCID: PMC3704951.

    Majumdar S, Kotecha M, Triplett W, Epel B, Halpern H. A DTI study to probe tumor microstructure and its connection with hypoxia. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:738-41. doi: 10.1109/EMBC.2014.6943696. PubMed PMID: 25570064; PMCID: PMC4324572.

    Makinen MW, Bamba R, Ikejimba L, Wietholt C, Chen CT, Conzen SD. The vanadyl chelate bis(acetylacetonato)oxovanadium(IV) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-D-glucose by cultured human breast carcinoma cells. Dalton Trans. 2013;42(33):11862-7. doi: 10.1039/c3dt50549a. PubMed PMID: 23644715; PMCID: PMC3733664.

    Markiewicz E, Fan X, Mustafi D, Zamora M, Roman BB, Jansen SA, Macleod K, Conzen SD, Karczmar GS. High resolution 3D MRI of mouse mammary glands with intra-ductal injection of contrast media. Magn Reson Imaging. 2015;33(1):161-5. doi: 10.1016/j.mri.2014.08.035. PubMed PMID: 25179139; PMCID: PMC4267960.

    Os Mustafi, D., J. Ward, U. Dougherty, M. Bissonnette, J. Hart, S. Vogt, and G. S. Karczmar. "X-Ray Fluorescence Microscopy Demonstrates Preferential Accumulation of a Vanadium-Based Magnetic Resonance Imaging Contrast Agent in Murine Colonic Tumors." Mol Imaging 14 (2015).

    Mustafi, D., M. Zamora, X. Fan, E. Markiewicz, J. Mueller, S. D. Conzen, and G. S. Karczmar. "Mri Accurately Identifies Early Murine Mammary Cancers and Reliably Differentiates between in Situ and Invasive Cancer: Correlation of Mri with Histology." NMR Biomed 28, no. 9 (Sep 2015): 1078-86.hima G, Stack ME, Wightman SC, Bryan D, Poli E, Xue L, Skowron KB, Uppal A, Pitroda SP, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones. J Vis Exp. 2016(117). doi: 10.3791/54657. PubMed PMID: 27929457.

    Oshima G, Stack ME, Wightman SC, Bryan D, Poli E, Xue L, Skowron KB, Uppal A, Pitroda SP, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones. J Vis Exp , 2016.

    Oshima G, Wightman SC, Uppal A, Stack ME, Pitroda SP, Oskvarek JJ, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Imaging of tumor clones with differential liver colonization. Sci Rep. 2015;5:10946. doi: 10.1038/srep10946. PubMed PMID: 26094901; PMCID: PMC4476146.

    Park S, Choi J, Biering SB, Dominici E, Williams LE, Hwang S. Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy. Autophagy 12:1153-67, 2016. PMC4990996

    Redler G, Barth ED, Bauer KS, Kao JP, Rosen GM, Halpern HJ. In vivo electron paramagnetic resonance imaging of differential tumor targeting using cis-3,4-di(acetoxymethoxycarbonyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl. Magn Reson Med. 2014;71(4):1650-6. doi: 10.1002/mrm.24813. PubMed PMID: 23776127; PMCID: PMC4321903.

    Redler G, Elas M, Epel B, Barth ED, Halpern HJ. Radiation oxygen biology with pulse electron paramagnetic resonance imaging in animal tumors. Adv Exp Med Biol. 2013;789:399-404. doi: 10.1007/978-1-4614-7411-1_53. PubMed PMID: 23852521; PMCID: PMC4319364.

    Redler G, Epel B, Halpern HJ. EPR image based oxygen movies for transient hypoxia. Adv Exp Med Biol. 2014;812:127-33. doi: 10.1007/978-1-4939-0620-8_17. PubMed PMID: 24729224; PMCID: PMC4313543.

    Redler G, Epel B, Halpern HJ. Principal component analysis enhances SNR for dynamic electron paramagnetic resonance oxygen imaging of cycling hypoxia in vivo. Magn Reson Med. 2014;71(1):440-50. doi: 10.1002/mrm.24631. PubMed PMID: 23401214; PMCID: PMC3796058.

    Redler G, Qiao Z, Epel B, Halpern HJ. Real-Time Image Reconstruction for Pulse EPR Oxygen Imaging Using a GPU and Lookup Table Parameter Fitting. Concepts Magn Reson Part B Magn Reson Eng. 2015;45(1):46-57. doi: 10.1002/cmr.b.21281. PubMed PMID: 26167137; PMCID: PMC4493913.

    Shenaq, D. S., C. M. Teven, I. A. Seitz, F. Rastegar, M. R. Greives, T. C. He, and R. R. Reid. "Characterization of Reversibly Immortalized Calvarial Mesenchymal Progenitor Cells." J Craniofac Surg 26, no. 4 (Jun 2015): 1207-13.

    Skowron KB, Pitroda SP, Namm JP, Balogun O, Beckett MA, Zenner ML, Fayanju O, Huang X, Fernandez C, Zheng W, Qiao G, Chin R, Kron SJ, Khodarev NN, Posner MC, Steinberg GD, Weichselbaum RR. Basal Tumor Cell Isolation and Patient-Derived Xenograft Engraftment Identify High-Risk Clinical Bladder Cancers. Sci Rep 6:35854, 2016. PMC5075783

    Souris JS, Hickson JA, Msezane L, Rinker-Schaeffer CW, Chen CT. Flexible peritoneal windows for quantitative fluorescence and bioluminescence preclinical imaging. Mol Imaging. 2013;12(1):28-38. PubMed PMID: 23348789.

    Uchiyama K, Sakiyama T, Hasebe T, Musch MW, Miyoshi H, Nakagawa Y, He TC, Lichtenstein L, Naito Y, Itoh Y, Yoshikawa T, Jabri B, Stappenbeck T, Chang EB. Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development. Sci Rep 6:32094, 2016. PMC4999796

    Wang CZ, Zhang Z, Wan JY, Zhang CF, Anderson S, He X, Yu C, He TC, Qi LW, Yuan CS. Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer. Nutrients. 2015;7(2):799-814. doi: 10.3390/nu7020799. PubMed PMID: 25625815; PMCID: PMC4344561.

    Xu R, Wang Y, Duan X, Lu K, Micheroni D, Hu A, Lin W. Nanoscale Metal-Organic Frameworks for Ratiometric Oxygen Sensing in Live Cells. J Am Chem Soc 138:2158-61, 2016. PMC5139906

    Zhang W, Zhang H, Wang N, Zhao C, Deng F, Wu N, He Y, Chen X, Zhang J, Wen S, Liao Z, Zhang Q, Zhang Z, Liu W, Yan Z, Luu HH, Haydon RC, Zhou L, He TC. Modulation of β-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways. Int J Med Sci. 2013;10(13):1888-98. doi: 10.7150/ijms.6019. PubMed PMID: 24324366; PMCID: PMC3856380.

    Zhang Y, Kenny HA, Swindell EP, Mitra AK, Hankins PL, Ahn RW, Gwin K, Mazar AP, O'Halloran TV, Lengyel E. Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy. Mol Cancer Ther. 2013;12(12):2628-39. doi: 10.1158/1535-7163.MCT-13-0204. PubMed PMID: 24061648; PMCID: PMC3885360.

    Zhang Y, Sriraman SK, Kenny HA, Luther E, Torchilin V, Lengyel E. Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform. Mol Cancer Ther. 2016;15(10):2282-93. doi: 10.1158/1535-7163.MCT-15-0986. PubMed PMID: 27466355; PMCID: PMC5050109.

    Zhang J, Zhang Z, Chukkapalli V, Nchoutmboube JA, Li J, Randall G, Belov GA, Wang X. Positive-strand RNA viruses stimulate host phosphatidylcholine synthesis at viral replication sites. PNAS 113:E1064-73, 2016. PMC4776486